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Search Result

Search Results for " pol ii "

Targets

CDK

9

Compounds

1

Natural Products

4

Recombinant Proteins

Cat No. Product Name Synonyms Targets
T22461 YKL-5-124 CDK
YKL-5-124, a potent, selective and covalent CDK7 inhibitor with an IC50 of 9.7 nM, 1300 nM and 3020 nM for CDK7/Mat1/CycH, CDK2 and CDK9 respectively, displays biochemical and cellular selectivity for CDK7 over CDK12/13...
T16867 SEC inhibitor KL-1 KL-1 Others
SEC inhibitor KL-1 (KL-1) exhibits a dose-dependent inhibitory effect on AFF4-CCNT1 interaction (Ki: 3.48 μM). SEC inhibitor KL-1 is a potent, selective super elongation complex (SEC) inhibitor and disrupts the interacti...
T16868 SEC inhibitor KL-2 KL-2 Others
SEC inhibitor KL-2 (KL-2) (KL-2) is a potent, selective super elongation complex (SEC) inhibitor. SEC inhibitor KL-2 exhibits a dose-dependent inhibitory effect on AFF4-CCNT1 interaction (Ki: 1.50 μM).
T64150 CX-5461 dihydrochloride
CX-5461 dihydrochloride is a potent, orally active inhibitor of Pol I-mediated rRNA synthesis that acts on HCT-116 cells (IC50: 142 nM), A375 cells (IC50: 113 nM) and MIA PaCa-2 cells (IC50: 54 nM), and to a lesser exten...
T69908 Pidnarulex HCl
Pidnarulex HCl is the salt form of CX-5461, a first-in-class non-genotoxic small molecule targeted inhibitor of RNA polymerase I (Pol I) that activates the p53 pathway without causing DNA damage. CX-5461 selectively inhi...
T74631 RNA polymerase II-IN-2
RNA polymerase II-IN-2 (compound 20iii), a potent inhibitor of RNA polymerase II (Pol II) with a K i value of 9.5 nM, demonstrates cytotoxicity against cancer cells, exhibiting toxicity levels 2 and 5 times higher than α...
T74630 RNA polymerase II-IN-1 DNA/RNA Synthesis
RNA polymerase II-IN-1 (compound 19iv), an amatoxin, selectively inhibits RNA polymerase II (Pol II) with an IC50 of 36.66 nM. It exhibits heightened cytotoxicity towards cancer cells and reduced toxicity in normal cells...
T69931 MFH290
MFH290 is a novel cysteine (Cys)-directed covalent inhibitor of CDK12/13. MFH290 forms a covalent bond with Cys-1039 of CDK12, exhibits excellent kinome selectivity, inhibits the phosphorylation of serine-2 in the C-term...
T82758 CDK9-Cyclin T1 PPI-IN-1 CDK
CDK9-Cyclin T1 PPI-IN-1 (Compound B19) is a selective inhibitor of the CDK9-Cyclin T1 protein-protein interaction (PPI), suppressing cell proliferation in TNBC MDA-MB-231 cells with an IC50 of 0.044 μM and inducing apopt...
Cat No. Product Name Synonyms Targets
T17143 Toyocamycin Vengicide Apoptosis , Others , IRE1 , Antibiotic , Antifungal
Toyocamycin (Vengicide) is an adenosine analog produced by Actinomycete, acts as an XBP1 inhibitor, inhibits IRE1α-induced ATP-dependent XBP1 mRNA cleavage (IC50: 80 nM). Toyocamycin induces apoptosis.

Natural Products

Toyocamycin
T17143
Synonym: Vengicide
Target: Apoptosis, Others, IRE1, Antibiotic, Antifungal

Recombinant Proteins

Species：
Cenarchaeum symbiosum (1)
E. coli (1)
HDV (1)
Kluyveromyces marxianus (1)
Expression System：
E. coli (3)
P. pastoris (Yeast) (1)
Tag：
N-10xHis, C-Myc (1)
N-6xHis (1)
N-6xHis, C-Myc (1)
Tag Free (1)
Cat No. Product Name Species Expression System
TMPH-00613 DNA polymerase II Protein, E. coli, Recombinant (His & Myc) E. coli E. coli
Thought to be involved in DNA repair and/or mutagenesis. Its processivity is enhanced by the beta sliding clamp (dnaN) and clamp loader.
TMPH-00360 DNA polymerase II large subunit Protein, Cenarchaeum symbiosum, Recombinant Cenarchaeum symbiosum E. coli
Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicativ...
TMPH-02380 RPB5 Protein, Kluyveromyces marxianus, Recombinant (His) Kluyveromyces marxianus E. coli
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precurs...
TMPH-00811 Hepatitis delta virus genotype I (HDV) Small delta antigen Protein (His & Myc) HDV P. pastoris (Yeast)
Promotes both transcription and replication of genomic RNA. Following virus entry into host cell, provides nuclear import of HDV RNPs thanks to its nuclear localization signal. May interact with host RNA polymerase II th...
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